Integrity laboratories8/3/2023 The germ lines must ensure transmission of the genetic information to the offsprings and must be very effective in the DNA integrity maintenance. They have significantly different demands for the genetic stability. This research interest originates from the existence of the two greatly distinct cell lines in animals: germ cells and somatic cells. Research Chromosome dynamics and integrity in female meiosis Our laboratory is an integral part of Pigmod Center supported by the project Experimental Animal Models (EXAM). In our group we use mainly quantitative fluorescence imaging techniques both in fixed and live cells to address the topic of genome integrity in mammalian oocytes in connection to infertility and neurological Huntington’s disease. However, compromised DNA integrity has also clear link to non-cancerous diseases such as infertility or neurological disorders. Compromised DNA integrity is widely connected to cancer. ![]() The cells possess very sophisticated mechanisms that recognize DNA damage and induce DNA repair – DNA damage response (DDR). All chromosomes (and mitochondrial DNA) form the genome. DNA in the nucleus of the cell is organised into the individual chromosomes. The live of all organisms including human insist on the integrity of information stored in DNA. Introduction to the group and its research Objev funkce tří Aurora kináz v savčích oocytech a reprodukci.Your browser does not support the video tag.ĭownload links: video and English subtitles.
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